Research demonstrates that cancer patients who stay engaged do better and live longer, more fulfilled lives!

Our experience shows that you only have to engage with your plan for as little as one hour a day to become on of the lucky patients when it comes to beating cancer.

These biomarkers are tied to the healthstyle suggestions and modules we have determined will give you better cancer outcomes. Setting routines and being able to visualize yourself as a cancer-free person who will someday help others is key to your success.

All you have to do is stay engaged, work your plan, and keep your eye on the prize with us cheering you on.

Collecting biomarker data is easy. Most are collected passively via a Fitbit, Breezing, or Activ5 device and the SuperBetter app. Others are collected via D-Terminator test kits, short questionnaires, and blood labs.

D-Terminator Test Kits    

Use D-Terminator test kits to track the deuterium in your body, food, beverages, and the air you breathe. 

Fitbit Trackers   

Your Fitbit device and app do most of the passive data collection. Use it to track:

• Health metrics
• Cardio exercise
• Stress
• Sleep
• Control Pause
• What you eat
• What you drink

Breezing 

Use this device to track your RMR (resting metabolic rate) and EMR (exercise metabolic rate) 

Activ5   

Use this device to track the strength of your different muscle groups, grip strength, and pliability (how well you are able to stretch). The Activ5 is also a full resistance training device even though it is pocket size. It is used by teams in the NBA and NFL. However, you can still train at your local or home gym and then use the device to track your strength changes.  

SuperBetter   

Play this game at least 10 minutes a day for at least a month or two to build up and track your physical, emotional, mental, and social resilience.

Questionnaires   

We will use forms to track your quality of life and program progress.  

Blood labs 

Blood biomarkers are collected via blood tests.

PHYSICAL BIOMARKERS    

Deuterium Levels    

Track using a D-Terminator test at the beginning of your program, and then at the end of every DDW change.

Your deuterium level should be below 130 ppm within 5 weeks of starting the program and then decrease with each DDW step down and as your sleep, breathing, digestion, exercise, etc. are optimized.   

Morning Control Pause (MCP) and Control Pause (CP) 

MCP - Wake up and immediately sit up on the side of the bed with your back straight and legs hanging over the side of the mattress - measure your MCP near-daily or daily.

CP - Sit down on a chair or couch with your back straight and feet on the floor - measure your CP at the same time each day, at least an hour or two after your last meal. 

Red Zone < 25 seconds, Yellow Zone > 25 seconds to 45 seconds, Green Zone >45 seconds

Resting Metabolic Rate (RMR)

RMR (the number of calories your body needs to function at rest) is best measured using a Breezing device - a handheld device that takes the place of a metabolic chamber and calculates the rate using the CO2 and oxygen in your breath. Breezing devices can be rented or purchased from BCO.

You can also use an equation to calculate an approximate static RMR, although it isn't as accurate as Breezing.

Men:  1.1 x (88.362 + (13.397 x weight in kg) + (4.799 x height in cm) – (5.677 x age in years))

Women: 1.1 x (447.593 + (9.247 x weight in kg) + (3.098 x height in cm) – (4.330 x age in years)

You should measure your RMR at least once every three months since it will change as your metabolism gets stronger and weaker during your cancer journey.  

Sleep Metrics 

Wear your Fitbit device to bed and allow it to collect your sleep data. You will want to routinely collect your sleep data at the beginning of your program and when you're working to optimize or investigate your sleep metrics.

Red Zone < 75 sleep score, Yellow Zone 75 seconds to 85 sleep score, Green Zone >85 sleep score

Therapeutic sleep qualifiers - i.e., sleep patterns must have these parameters: 7-8.5 hours of sleep: 5-12% awake, 15-25% REM, 40-50% light, 15-25% deep, no significant awakenings during the night, no constant night awakenings, no consistent high estimated oxygen variation. 

Muscle Strength   

This is best done with the Activ5 device from the Exercise Right module or using a device to measure your grip strength. This measurement should be taken weekly as it is an insightful way to keep an eye on you getting weaker or stronger during your cancer treatment and recovery.  This is also an excellent way to determine if your chosen or assigned exercise routine is effective, i.e., is it allowing you to maintain or increase your strength? 

Cardio/Exercise 

Wake up and exercise for up to 10 minutes as if you were being chased by a tiger, and your metabolism and blood glucose will improve. Use your Fitbit to track this activity.

This and taking a simple walk or walks totaling 2,500 to 10,000 steps each day is all we ask you to do. But feel free to do more without overdoing it. However, we suggest that you focus more on stretching and strength training rather than doing extra cardio.  

HRV   

Is measured passively during your sleep and tracked by your Fitbit.

Vitamin D   

Vitamin D may decrease tumor invasiveness and propensity to metastasize, leading to reduced cancer mortality. Higher serum 25-hydroxyvitamin D (25[OH]D) levels at diagnosis have been linked to longer survival in cancer patients. Take this measure monthly until you reach your desired level and then semiannually or annually.

The optimal range will be provided by BCO based on your cancer type and if you created your vitamin D level naturally or using supplements.  

Glucose/A1C    

Cancer is a ravenous consumer of deuterium-laden sugar. High blood sugar levels are also associated with inflammation, support bacterial, fungal, and viral growth, decreased energy, and blunted immune responses. All of these things are bad for cancer patients and those in remission, and you should initially measure your glucose levels regularly until you establish a healthstyle that keeps blood glucose low. You can then rely on using the A1C biomarker - the average blood glucose level over the last three months - to keep an eye on glucose rather than taking near-daily measurements. 

Optimal range - 64 to 80 mg/dL   

RESILIENCE BIOMARKERS  

Quality of Life   

A questionnaire to measure aspects of your sense of well-being and your ability to carry out activities of daily living. This questionnaire should be taken at the beginning of your program or early on in your program and then every quarter.    

Stress Score   

Measure passively by Fitbit.

Red Zone < TBD, Yellow Zone TBD, Green Zone >TBD

Physical Resilience   

One's ability to withstand or recover physically from the challenges and functional decline of cancer and cancer recovery. This is measured during 5 minutes of game time with our Super Better Cancer Outcomes program, which should be played near-daily when starting your program.    

Emotional Resilience   

One's ability to withstand or recover emotionally from the challenges and functional decline of cancer and cancer recovery. This is measured during 5 minutes of game time with our Super Better Cancer Outcomes program, which should be played near-daily when starting your program.  

Social Resilience   

One's ability to withstand or recover socially from the challenges and functional decline of cancer and cancer recovery. This is measured during 5 minutes of game time with our Super Better Cancer Outcomes program, which should be played near-daily when starting your program.  

Mental Resilience   

One's ability to withstand or recover mentally from the challenges and functional decline of cancer and cancer recovery. This is measured during 5 minutes of game time with our Super Better Cancer Outcomes program, which should be played near-daily when starting your program.  

FOOD BIOMARKERS 

Average Daily Total Calories

This data is best collected by recording what you eat in your Fitbit app, which will then calculate the amount of protein, fat, carbohydrates, added sugar, calories, etc., in your meals. What you eat can be entered into the app manually or using the app's AI-facilitated voice or picture entry system.   

Those in active treatment should eat no more than 110 to 120% of the calories required to satisfy their RMR. Those in remission should eat the number of calories more, less, or the same as their RMR value, depending on if they want to, respectively, gain, lose, or maintain weight.

Food Deuterium Content

Our calculations take the nutritional values from your Fitbit app and our deuterium food database to approximate the deuterium levels of the food you are eating. Follow your Eat Right and Keto Right module instructions to ensure you are eating a deuterium-reduced diet. 

Food Deuterium Reducing Capacity

Our calculations take the nutritional values from your Fitbit app that was used to calculate your total calories and use them to approximate the deuterium-reducing capacity of the food you eat. The biggest contributors are how plant-based your meals are, how much fiber is in your diet, and the amount and variety of the phytochemicals in your diet. 

Total Protein Intake

Our calculations take the nutritional values from your Fitbit app to calculate the protein in your diet.  

Total Methionine Intake

We use the nutritional values from your Fitbit app and how much of it came from animal sources or plant sources to calculate your methionine intake. Research studies support limiting methionine for cancer patients, with more than a handful of respected studies showing poorer clinical outcomes with diets rich in methionine-rich animal protein versus methionine-poor plant protein.

Water and Beverage Deuterium Content

This data is best collected by recording what you drink in your Fitbit app. You can tell the app how much you're drinking and when you're drinking, whether you're consuming 85 ppm DDW, bottled or tap water, juice, a smoothie, etc. We then use that data, along with the water in your food, to estimate the total daily water intake and its ppm. 

Your goal will be to consume the combination of water that provides put your Drink Right module at one 1 DDU (deuterium depletion unit). The DDU is calculated from a combination of your weight and the ppm and volume of the water you consume. The optimal zone is 1 DDU or greater.